Bibliografía

• All-Arthroscopic Nanofractured Autologous Matrix-Induced Chondrogenesis (A-NAMIC) Technique for the Treatment of Focal Chondral Lesions of the Knee. Arthroscopy Techniques. The journal of Arthroscopic and related surgery 2020/ Peñalver et al, Villalba et. al.
• Second Generation Needling Techniques for the Treatment of Chondral Defects in Animal Model Joints 2017/ Zedde et. al., Cudoni et. al.
• Subchondral bone remodelling: comparing nano fracture with microfracture. An ovine in vivo study. Joints 2016/ Zedde et. al.
• The Effect of Different Bone Marrow Stimulation Techniques on Human Talar Subchondral Bone: A MicroeComputed Tomography Evaluation. The Journal of Arthroscopy and Related Surgery 2016/ Arianna et. al.
• Small Subchondral Drill Holes Improve Marrow Stimulation of Articular Cartilage Defects. Am.J. Sports Med 2014/ Eldracher et. al.
• Efficacy of Marrow-Stimulating Technique in Arthroscopic Rotator Cuff Repair: A Prospective Randomized Study. The Journal of Arthroscopy and Related Surgery 2013 / Milano et. al.
• Depth of Subchondral Perforation Influences the Outcome of Bone Marrow Stimulation Cartilage Repair. J. Of Orthopaedic Research 2011/ Chen et. al.
• Characterization of Subchondral Bone Repair for Marrow-Stimulated Chondral Defects and Its Relationship to Articular Cartilage Resurfacing. Am J Sports Med 2011/ Chen et. al.

Publicaciones Pre-Clínicas:

• Growth Factor Delivery to a Cartilage-Cartilage Interface Using Platelet-Rich Concentrates on a Hyaluronic Acid Scaffold. The Journal of Arthroscopic and Related Surgery; may 2020; (36):1431-1440 / Ashley Titan et. al., M.D., Michael Schärournal et. al.
• Combination of Mesenchymal Stem Cells, Cartilage Pellet and Bioscaffold Supported Cartilage Regeneration of a Full Thickness Articular Surface Defect in Rabbits. Tissue Eng Regen Med. 2018/ Mohammed Abbas et al.
• Chondrogenic differentiation of bone marrow concentrate grown onto a hylauronan scaffold: Rationale for its use in the treatment of cartilage lesions. J Biomed Mater Res A. 2012 Nov. 7/ Cavallo C. et. al., Desando G. et. al.
• Osteoarthritis treated with mesenchymal stem cells on hyaluronan-based scaffold in rabbit. TISSUE ENG PART C Volume 15, Number 4, 2009 (647-658)/ Grigolo B. et. al., Lisignoli G. et. al.
• Osteogenic and chondrogenic differentiation: comparison of human and rat bone marrow mesenchymal stem cells cultured into polymeric scaffolds. European Journal of Hystochemistry 2007; vol. 51 supplement 1:1-8/ Zavan B. et. al., Giorgi C. et. al., Bagnara G.P et. al.
• Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: involvement of Cd44 and Cd54. Journal of cellular Physiology 207: 364-373 (2006)/ Lisignoli G. et. al, Cristino S., et. al.
• Chondrogenic differentiation of murine and human mesenchymal stromal cells in a hyaluronic acid scaffold: differences in gene expression and cell morphology. J BIOMED MATER RES A. 2006 Jun 1;77(3):497-506/ Lisignoli G.et. al., Cristino S. et. al., Piacentini A, et. al.
• Human chondrocytes and mesenchymal stem cells grown onto engineered scaffold. Biorheology 2006; 43 (3-4): 471-80/ Facchini A.et. al., Lisignoli G. et. al.
• Cellular and molecular events during chondrogenesis of human mesenchymal stromal cells grown in a three-dimensional hyaluronan based scaffold . BIOMATERIALS 2005;(26):5677-5686 / Lisignoli G.et. al., Cristino S.et. al.
• Evidence for redifferentiation of human chondrocytes grown on a hyaluronan-based biomaterial (HYAff 11): molecular, immunohistochemical and ultrastructural analysis BIOMATERIALS 2002 Feb;23(4):1187-95. doi: 10.1016/s0142-9612(01)00236-8./ Grigolo B. et. al., Lisignoli G. et. al.

Publicaciones Clínicas:

• Biological resurfacing of grade IV articular cartilage ulcers in knee joint with Hyalofast. Journal of Orthopaedic Surgery (January), 2020/ Ia Tan  et al, Jun Wei Tho et al.
• A Technique Using a Low-Cost, Accessible Cannula to Aid Scaffold Passage in Dry Arthroscopic Cartilage Repair in the Knee. Arthroscopy Techniques, Vol 9, No 6 (June), 2020: pp e775-e782/ Chou  et al.
• A useful combination for the treatment of patellofemoral chondral lesions: realignment procedure plus mesenchymal stem cell – retrospective analysis and clinical results at 48 months of follow up. European Journal of Orthopaedic Surgery & Traumatology 2019/ Buda et al.
  
• Long-term Clinical Outcomes of One-Stage Cartilage Repair in the Knee With Hyaluronic Acid-Based Scaffold Embedded With Mesenchymal Stem Cells Sourced From Bone Marrow Aspirate Concentrate. The American Journal of Sports Medicine 2019 / Gobbi et al.
• Osteochondral Lesions of the Femoral Condyles: Are the Results of the One-Step Repair Technique Still Satisfactory at Longterm? Abstract ISAKOS congress 12-15 May 2019/ Buda R et al.
• One step surgery with multipotent stem cells and Hyaluronan based scaffold for the treatment of full thickness chondral defects of the knee in patients older than 45 years. Knee Surg Sports Traumatol Arthrosc 2017 / Gobbi et al.
• Results of Hyaluronic Acide Based Cell-Free Scaffold Application in Combination with Microfracture for the Treatment of Osteochondral Lesions of the Knee: 2- Year Comparative Study. Arthroscopic  2017/ Gobbi et al.
• Arthroscopic treatment of osteochondral lesions of the talus: nanofracture vs Hyaluronic acid-based cell-free scaffold with concentration of autologous bone marrow aspirate. J Orthop Surg  2017 / Tahta M., et al.
• Dry Arthroscopic Single-Stage Cartilage Repair of the Knee Using a Hyaluronic Acid-Based Scaffold With Activated Bone Marrow-Derived Mesenchymal Stem Cells Arthroscopy Techniques Volume 5, Issue 4, August 2016/G. P. Whyte et. al., A. Gobbi et.al, B. Sadlik et. al.
• One-Stage Cartilage Repair Using a Hyaluronic Acid-Based Scaffold With Activated Bone Marrow-Deirved Mesenchymal Stem Cells Compared With Microfracture. Fice-Year Follow-up. The American Journal of Sport Medicine 2016/ Gobbi et al.
• “One-step” bone marrow-derived cells transplantation and joint debridement for osteochondral lesions of the talus in ankle osteoarthritis: clinical and radiological outcomes at 36 months. Arch Orthop Trauma Surg 2015/Buda et al.
• Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation. International Orthopaedics (SICOT) 2015/ Buda et al.
• Matrix-Induced Autologous Chondrocyte Implantation versus Multipotent Stem Cells for the treatment of large patellofemoral chondral lesions: a non-randomized prospective trial. Cartilage 2014 / Gobbi et al.
• One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: three years results. Musculoskelet Surg. 2013 Feb 19/Buda et al.
• One Step Treatment of Juvenile Osteochondritis Dissecans in the Knee: clinical results and T2 mapping Characterization. Orthop Clin N Am, 2012 / Vannini F. et al.
• One step Bone Marrow-derived cell Transplantation in Talar Osteochondral Lesions. Clin Orthop Relat Res, Dec; 467 (12):3307-20./ Giannini S. et al.
• Validity of T2 mapping in characterization of the regeneration tissue by bone marrow derived cell transplantation in osteochondral lesions of the ankle. Eur J Radiol. 2010 / Battaglia M., et al.
• Osteochondral lesions of the knee: a new one-step repair technique with bone-marrow-derived cells. J Bone Joint Surg Am. 2010 Dec / Buda R, et al.
• Cartilage repair evolution in post-traumatic osteochondral lesions of the talus: From open field autologous chondrocyte to bone-marrow-derived cells transplantation. Injury, 2010 Nov./ Giannini S, et al.

White Papers:

• HYALOFAST®, a new biological approach for chondral and osteochondral lesion treatment. Author: Longinotti C. et. al.

Descargar el documento HYALOFAST White paper

• All-Arthroscopic Nanofractured Autologous Matrix-Induced Chondrogenesis (A-NAMIC) Technique for the Treatment of Focal Chondral Lesions of the Knee. Arthroscopy Techniques. The journal of Arthroscopic and related surgery June 2020/ Peñalver et al, Villalba et al.
• Autologous Matrix-Induced Chondrogenesis for Osteochondral Lesions of the Talus: A Clinical and Radiological 2- to 8-Year Follow-up Study Am J Sports Med. 2019 / Lizzy Weigelt et. al. , Rebecca Hartmann et. al., Christian Pfirrmann et. al.
• All-Arthroscopic Autologous Matrix-Induced Chondrogenesis-Aided Repair of a Patellar Cartilage Defect Using Dry Arthroscopy and a Retraction System. J Knee Surg 2017 / Sadlik et al. 
• Osteochondral Lesions of the Talus and Autologous Matrix-Induced Chondrogenesis: Is Age a Negative Predictor Outcome? Arthroscopy: The Journal of Arthroscopic & Related Surgery Volume 33, Issue 2, February 2017, Pages 428-435/ R. D’Ambrosi et al, C. Maccario et. al. N. Serra et. al. F. Liuni et. al. F. G. Usuelli et. al.
• Sustained five-year benefit of autologous matrix-induced chondrogenesis for femoral acetabular impingement-induced chondral lesions compared with microfracture treatment. Journal of Bone & Joint 2015 / Fontana et al.
• All-Arthroscopic Autologous Matrix-Induced Chondrogenesis for the Treatment of Osteochondral Lesions of the Talus.Arthrosc Tech. 2015 Jun; 4(3): e255–e259 / F. G. Usuelli et. al., L. de Girolamo et. al., M. Grassi et. al.
• Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Two-Year Follow-up of a Prospective Randomized Trial. Am.J. Sports Med 2014 / Saris et al.
• One-step surgery with multipoint stem cells for the treatment of large full-thickness chondral defects of the knee. Am J Sports Med 2013/ Gobbi et al.
• Minimum ten-year results of a prospective randomised study of autologous chondrocyte implantation versus mosaicplasty for symptomatic articular cartilage lesions of the knee. J Bone Joint Surg Br. 2012/ Betley G, Biant LC et al.

• Treatment of osteochondritis dissecans of the patella in adolescents with nanofractured autologous matrix-induced chondrogenesis (NAMIC): A report of five cases.  / The Knee Volume 30, June 2021, Pages 157-162/ J. Villalba et. al, J. Sánchez et. al., J.M. Peñalver et. al.
• Treatment of big osteochondral defects in the lateral femoral condyle in young patients with autologous graft and collagen mesh. Journal of Orthopaedic Surgery and Traumatology (Article in press) S.E.C.O.T abril 2021/ J.Villalba et al., J.M.Peñalver et. al, J. Sánchez et. al.
• Management of Patellar Chondral Defects with Autologous Matrix Induced Chondrogenesis (AMIC) Compared to Microfractures: A Four Years Follow-Up Clinical Trial. Life (Basel). 2021 Feb 13;11(2):141. doi: 10.3390/life11020141/ Filippo Migliorini et. al. , Jörg Eschweiler et. al. , Nicola Maffulli et. al
• A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over micro fracture at five years. Int Ortho 2017 / Volz M, Andres S et al.
• Clinical Results 10 years after AMIC in the knee. ESSKA 2016 / N.Kaiser et al.
• Nanofractured autologous matrixinduced chondrogenesis (NAMIC©) Further development of collagen membrane aided chondrogenesis combined with subchondral needling. The Knee 2015 / J.P. Benthien, P. Behrens.
• Clinical and radiological long-term outcomes after matrix-induced autologous chondrocyte transplantation: a prospective follow-up at a minimum of 10 years. Am.J. Sports Med 2012 /Aldrian et al.
• Use of collagen scaffold and autologous bone marrow concentrate as a one-step cartilage repair in the knee: histological results of second-look biopsies. Int. J. Immunopathol Pharmacol 2011 / Gigante et al.
• Cell carriers as the next generation of cell therapy for cartilage repair: a review of the matrix-induced autologous chondrocyte implantation procedure. Am J Sports Med 2010 / Brittberg et al.
• Use of collagen scaffold and autologous bone marrow concentrate as a one-step cartilage repair in the knee: histological results of second-look biopsies. Int. J. Immunopathol Pharmacol 2011 / Gigante et al.

• High patient satisfaction with significant improvement in knee function and pain relief after mid-term follow-up in patients with isolated patellofemoral inlay arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2019 Jul;27(7):2251-2258 / Imhoff et. al
• The clinical outcome of the different HemiCAP and UniCAP knee implants: A systematic and comprehensive review. Orthop Rev (Pavia) 10(2): 7531 2018 / Malahias et al.
• Early results of patellofemoral inlay resurfacing arthroplasty using the HemiCap Wave prosthesis. Journal of Orthopaedic Surgery 25(1)1-5 2017 / Patel et al.
• A matched-pair comparison of inlay and only trochlear designs for patellofemoral arthroplasty, less progression of osteoarthritis with inlay designs. Knee Surg Sports Traumatol Arthrosc 2015 / Imhoff et al.
• Patellofemoral Resurfacing Arthroplasty in the Active Patient. Springer: pp 131-150. 2014 / Arendt E. et al.
• Prospective Evaluation of Anatomic Patellofemoral Inlay Resurfacing: Clinical, Radiographic, and Sports-Related Results After 24 Months. Knee Surg Sports Traumatol Arthrosc 2013 / Cotic et al.
• Focal Full Thickness Articular Cartilage Lesions Treated with an Articular Resurfacing Prosthesis in the Middle-Aged. SA Orthop J 2013: 12(4):41-46 / Hobbs et al.
• Patellofemoral Kinematics After Limited Resurfacing of the Trochlea. J Knee Surg.; 22:310-316. 2009 / Bach et al.
• Focal Anatomic Patellofemoral Inlay Resurfacing: Theoretic Basis, Surgical Technique, and Case Reports. Orthop Clin North Am. 2008 Jul;39(3):337-46 / Davidson et al.
• Patellofemoral Resurfacing Arthroplasty: Literature Review and Description of a Novel Technique. Iowa Orthop J. 2008;28:42-8 / Amendola et al.

• UniCAP as an Alternative for Unicompartmental Arthritis. Clin Sports Med. 2014 Jan;33(1):57-65. 2014 / Miniaci et al.
• Inlay Joint Resurfacing and High Tibial Osteotomy (HTO) in Middle-Aged Athletes. Sports Injuires: Springer-Verlag Berlin Heidelberg 2010 / Beyzadeoglu et al.
• Microartroplastia de Superficie y Osteotomía Tibial de Apertura Simultánea. ARTROSCOPIA | VOL. 20: Nº 1 : 202-205. 2013 / Autorino et al.